/  Rosario - Santa Fe - Argentina

 
 
     

 


 


Dr. José M. Conde
* Director médico del Hospital. Profesor titular del curso de Medicina Interna

Romero Salas Betzaida Arianne* Arango Salazar Gabriela* Hernández Flores Lizeth* Martínez Ramírez Griselda** José Manuel Conde Mercado

*Médicos Residentes de 3er año Medicina Interna ** Médico Residente de 4to año Medicina Interna + Director Médico


 



 

 

 

 

Interrupción diaria de la sedación en pacientes con ventilación mecánica

Dr.José M. Conde
 

Bibliografía

  1. Ramos Delgado I.et al. Analgesia y sedación del paciente critico en ventilación mecánica. Rev Esp, Anestesiol Reanim. 2007;54, 302-312.
  2. Martin E, Ramsay G, Mantz J, Sum-Ping STJ: The role of the a2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care. J Intensive Care Med 2003, 18:29-41.
  3. Shapiro BA, Warren J, et al; Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine. Crit Care Med 1995, 23:1596-1600.
  4. Pasternak GW, Bodnar RJ, Clark JA, Inturrisi CE: Morphine-6-glucuronide, a potent mu agonist. Life Sci 1987, 41:2845-2849.
  5. Frances B, Gout R, Campistron G, Panconi E, Cros J: Morphine-6-glucuronide is more mu-selective and potent in analgesic tests than morphine. Prog Clin Biol Res 1990, 328:477-480
  6. Macintire PE, Jarvas DA: Age is the best predictor of postoperative morphine requiriments. Pain 1995; 64:357-64.
  7. Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y. Delirium in an intensive care unit: A study of risk factors. Intensive Care Med. 2001;27(8):1297-304.
  8. Marcantonio ER, Juarez G, Goldman L, Mangione CM, Ludwig LE, Lind L, et al. The relationship of postoperative delirium with psychoactive medications. JAMA. 1994;272(19):1518-22.
  9. Ely EW, Gautam S, Margolin R, Francis J, May L, Speroff T, et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med. 2001;27(12):1892-900.
  10. Ely EW, Shintani A, Bernard G et al. Delirium in the ICU is associated with prolonged length of stay in the hospital and higher mortality. Am J Respir Crit Care Med. 2002;165:A23.
  11. Sun X, Weissman C: The use of analgesics and sedatives in critically ill patients: physicians' orders versus medications administered. Heart Lung 1994; 23:169-76
  12. Curtis N. Sessler and Kimberly Varney. Patient-focused sedation and analgesia in the ICU. Chest 2008;133;552-565
  13. Evaluating and monitoring analgesia and sedation in the intensive care unit Curtis N Sessler1,2, Mary Jo Grap3 and Michael AE Ramsay4 Published: 14 May 2008 Critical Care 2008, 12(Suppl 3):S2 (doi:10.1186/cc6148)
  14. Young J, Siffleet J, Nikoletti S, Shaw T: Use of a Behavioural Pain Scale to assess pain in ventilated, unconscious and/or sedated patients. Intensive Crit Care Nurs 2006, 22:32-39.
  15. Sedation practice in the intensive care unit: a UK national survey; Henrik Reschreiter1, Matt Maiden1 and Atul Kapila; Critical Care 2008, 12:R152 (doi:10.1186/cc7141)
  16. Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW: Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006, 104:21-26.
  17. Kress JP, Pohlman AS, Hall JB. Effects of sedative interruption in critically ill, mechanically ventilated patients receiving midazolam or propofol.  J Clin Outcomes Manage 2001;8:33–3
  18.  Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman. G: The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest 1998, 114:541-548
  19. Chanques G, Jaber S, Barbotte E, Violet S, Sebbane M, Perrigault PF, Mann C, Lefrant JY, Eledjam JJ: Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med 2006, 34:1691-1699.
  20. Brook AD, Ahrens TS, Schaiff R, Prentice D, Sherman G,Shannon W, Kollef MH: Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. CritCare Med 1999, 27:2609-2615.
  21. De Jonghe B, Bastuji-Garin S, Fangio P, Lacherade JC, Jabot J,Appere-De-Vecchi C, Rocha N, Outin H: Sedation algorithm in/critically ill patients without acute brain injury. Crit Care Med 2005, 33:120-127.
  22. Marjolein de Wit, Chris gennings, Wendy I Jenvey and Scott Epstein: Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. Critical care Med 2008,
  23. Schweickert WD, Gehlbach BK, Pohlman AS, et al. Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med 2004; 32:1272–1276
  24. Heffner JE. A wake-up call in the intensive care unit. N Engl J Med 2000; 342:1520–1522
  25. Kress JP, Gehlbach B, Lacy M, et al. The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med 2003; 168: 1457–1461
  26. Kress JP, Vinayak AG, Levitt J, et al. Daily sedative interruption in mechanically ventilated patients at risk for coronary artery disease. Crit Care Med 2007; 35:365–371
  27. Sessler CN. Wake up and breathe. Crit Care Med 2004;32:1413–1414
  28. Jones C, Backman C, Capuzzo M, et al. Precipitants of post-traumatic stress disorder following intensive care: a hypothesis generating study of diversity in care. Intensive Care Med 2007; 33:978–985
  29. William D. Schweickert, et al, Daily interruption of sedative infusion and complications of critical illness in mechanically ventilated patients, Crit Care Med 2004 Vol.32, No 6
  30. Timothy D Girard et al, Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care ( Awakening and Breathing Controlled trial): a randomized controlled trial, Lancet 2008; 371:126-34
  31. William D Schweickert and John P Kress, Strategies to optimize analgesia and sedation, Crtical Care 2008, 12 (Suppl 3):S6
  32. John P. Kress et al; Daily interruption of sedative infusion in critically ill patients undergoing mechanical ventilation, N Eng J Med 2000; 342:1471-7


 

 

 
Índice
Introducción
Sedación
Analgesia
Delirium
Evaluación de sedación y analgesia
Protocolos de sedación

Interrupción diaria de la sedación en pacientes con ventilación mecánica
Conclusiones
Bibliografía
 
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