|
Los
antioxidantes son buenos… para quienes los venden, pero ¿y
para los pacientes?
Deliberadamente no hemos traducido las
conclusiones para evitar errores de traducción y o
interpretación.
Mortality
in Randomized
Trials of Antioxidant Supplements for Primary and Secondary
Prevention: Systematic Review and Meta-analysis
G Bjelakovic; D Nikolova; L Lotte Gluud ; RG Simonetti; C
Gluud
JAMA. 2007;297:842-857.
LINK :
http://jama.ama-assn.org/cgi/reprint/297/8/842
Conclusions: Treatment with beta carotene, vitamin A, and
vitamin E may increase mortality. The potential roles of
vitamin C and selenium on mortality need further study.
Más artículos relacionados:
·
Dietary antioxidants and primary prevention of age related
macular degeneration: systematic review and meta-analysis
EW Chong, TY Wong, AJ Kreis, JA Simpson, RH Guymer
BMJ 2007;335;755 - 13 October
http://www.bmj.com/cgi/reprint/335/7623/755
Conclusions: There is insufficient evidence to support the
role of dietary antioxidants, including the use of dietary
antioxidant supplements, for the primary prevention of early
AMD.
·
Randomized Trials of Vitamin E in the Treatment and
Prevention of Cardiovascular Disease
RS Eidelman; D Hollar; PR Hebert; GA Lamas; CH Hennekens
Arch Intern Med. 2004;164:1552-1556.
http://archinte.ama-assn.org/cgi/reprint/164/14/1552
Conclusions: The ORs and CIs provide strong support for a
lack of statistically significant or clinically important
effects of vitamin E on cardiovascular disease. The use of
agents of proven lack of benefit, especially those easily
available over the counter, may contribute to underuse of
agents of proven benefit and failure to adopt healthy
lifestyles.
·
REVIEW. Meta-Analysis: High-Dosage Vitamin E Supplementation
May Increase All-Cause Mortality
ER. Miller; R Pastor-Barriuso; D Dalal; RA. Riemersma; LJ.
Appel and E Guallar
Ann Intern Med. 2005;142:37-46 - 4 January
http://www.annals.org/cgi/reprint/142/1/37.pdf
Conclusion: High-dosage (400 IU/d) vitamin E supplements may
increase all-cause mortality and should be avoided
Effects of Long-term Vitamin E Supplementation on
Cardiovascular Events and Cancer A Randomized Controlled
Trial
The HOPE and HOPE-TOO Trial Investigators
JAMA. 2005;293:1338-1347. 16 March
http://jama.ama-assn.org/cgi/reprint/293/11/1338
Conclusion: In patients with vascular disease or diabetes
mellitus, long-term vitamin E supplementation does not
prevent cancer or major cardiovascular events and may
increase the risk for heart failure. |
